Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 91, Issue 3, Pages 204-214Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/icb.2012.80
Keywords
Intestinal epithelial cells; IEC; commensal bacteria; SFB; Th17; Treg
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Funding
- Japan Society for the Promotion of Science (JSPS)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Crohn's and Colitis Foundation of America (CCFA)
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Commensal bacteria regulate the homeostasis of host effector immune cell subsets. The mechanisms involved in this commensal host crosstalk are not well understood. Intestinal epithelial cells (IECs) not only create a physical barrier between the commensals and immune cells in host tissues, but also facilitate interactions between them. Perturbations of epithelial homeostasis or function lead to the development of intestinal disorders such as inflammatory bowel diseases (IBD) and intestinal cancer. IECs receive signals from commensals and produce effector immune molecules. IECs also affect the function of immune cells in the lamina propria. Here we discuss some of these properties of IECs that define them as innate immune cells. We focus on how IECs may integrate and transmit signals from individual commensal bacteria to mucosal innate and adaptive immune cells for the establishment of the unique mucosal immunological equilibrium. Immunology and Cell Biology (2013) 91, 204-214; doi:10.1038/icb.2012.80; published online 15 January 2013
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