Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 92, Issue 3, Pages 221-229Publisher
WILEY
DOI: 10.1038/icb.2013.98
Keywords
cancer; innate immunity; ILC; natural cytotoxicity receptor; NK cell; virus
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [KR 3692/2-1]
- Ministere de l'Enseignement Superieur et de la Recherche
- European Research Council (THINK Advanced Grant)
- INSERM
- CNRS
- Aix Marseille
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Natural killer (NK) cells are innate lymphoid cells (ILCs) that participate to the clearance of pathogen-infected cells and tumour cells. NK cells and subsets of ILCs express the natural cytotoxicity receptors (NCRs) NKp46, NKp44 and NKp30 at their surface. NCRs have been shown to recognize a broad spectrum of ligands ranging from viral-, parasite- and bacterial-derived ligands to cellular ligands; however, the full identification of NCR ligands remains to be performed and will undoubtedly contribute to a better understanding of NK cell and ILC biology.
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