Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 91, Issue 10, Pages 661-664Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/icb.2013.53
Keywords
cell death; inflammation; MAPK; NF kappa B; progranulin; TNF receptor 1
Categories
Funding
- National Health and Medical Research Council of Australia (NHMRC) [541901, 541902, 602516, 1022916, 1025594]
- Australian Government NHMRC IRIISS [361646]
- Swiss National Science Foundation (SNSF) [PA00P3_126249]
- Swiss National Science Foundation (SNF) [PA00P3_126249] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Progranulin (proepithelin, granulin precursor) has been recently suggested to exhibit anti-inflammatory properties by directly binding to tumour necrosis factor (TNF) receptors and thereby inhibiting TNF signalling by Tang et al. This finding was challenged by Chen et al. and no interaction between progranulin and TNF receptor (TNFR) 1 or 2 was observed. We tested the ability of recombinant progranulin from different commercial sources to inhibit TNF- or lymphotoxin-alpha-induced signalling through TNFR1. We observed that progranulin does not affect signalling and cell death induction downstream of TNF or lymphotoxin-alpha. Our results suggest that the anti-inflammatory role of progranulin is not mediated through direct inhibition of TNFR1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available