Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 90, Issue 9, Pages 889-895Publisher
WILEY
DOI: 10.1038/icb.2012.24
Keywords
Candida infections; C-type lectin; dichotomous expression; Mincle; monocytes; neutrophils
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Funding
- Australian National Health and Medical Research Council [455947]
- Australian Dental Research Foundation
- NHMRC CDA
- UQ
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The distribution and function of the C-type lectin Mincle has not previously been investigated in human cells, although mouse models have demonstrated a non-redundant role for Mincle in the host response to fungal infections. This study identified an unusual pattern of reciprocal expression of Mincle on peripheral blood monocytes or neutrophils isolated from the same donor. Expression on monocytes was inversely correlated with phagocytosis and yeast killing, but was necessary for the induction of inflammatory cytokines in response to ex vivo Candida challenge. In contrast, Mincle expression on neutrophils was associated with phagocytic and candidacidal potential of those cells. Candida challenge upregulated Mincle expression but only in Mincle+ cells. These data highlight species-specific differences between the regulation of Mincle expression in mouse and man. Reciprocal expression of Mincle modified the candidacidal potential of monocytes or neutrophils, suggesting it may also polarize the type of host response to fungal infection. Immunology and Cell Biology (2012) 90, 889-895; doi:10.1038/icb.2012.24; published online 29 May 2012
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