Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 90, Issue 9, Pages 852-859Publisher
WILEY
DOI: 10.1038/icb.2012.28
Keywords
SATB1; T helper cells; Wnt signaling; regulatory T cells
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Funding
- Centre of Excellence in Epigenetics program of the Department of Biotechnology, Government of India
- IISER Pune
- Council of Scientific and Industrial Research, India
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T-cell development and differentiation is coordinated by a multitude of signaling molecules and transcription factors that impart distinct functional properties to progenitors. In this review, we focus on the role of the T lineage-enriched chromatin organizer and regulator SATB1 in T-cell differentiation. SATB1 mediates Wnt signaling by recruiting beta-catenin to its genomic targets and coordinates T helper type 2 (T(H)2) differentiation by positively regulating GATA-3. In contrast, maintenance of regulatory T cell (Treg) functions are dependent on inhibition of SATB1-mediated modulation of global chromatin organization. We discuss how regulation of the activity of SATB1 has a critical role in driving these two important differentiation pathways in T cells. Immunology and Cell Biology (2012) 90, 852-859; doi:10.1038/icb.2012.28; published online 19 June 2012
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