Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 90, Issue 6, Pages 587-593Publisher
WILEY
DOI: 10.1038/icb.2011.74
Keywords
innate immunity; miRNAs; myeloid differentiation; transcription factors
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Funding
- NIAID NIH HHS [R01 AI079144, R01 AI065791] Funding Source: Medline
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MicroRNAs (miRNAs) are abundant small molecules of similar to 22 nucleotides that reprogram gene expression by targeting mRNA degradation and translation disruption. An emerging concept implicates miRNA coupling with transcription factors in myeloid-based development of dendritic cells, monocytes and granulocytes, as well as function as mature cells and contributors to host defense and inflammation. Here, we review this new and important interactive circuitry and how it contributes to reprogramming cell phenotypic responses associated with mature immune competency. Immunology and Cell Biology (2012) 90, 587-593; doi:10.1038/icb.2011.74; published online 13 September 2011
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