Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 89, Issue 1, Pages 7-13Publisher
WILEY
DOI: 10.1038/icb.2010.110
Keywords
blood monocytes; T-cell suppression; nitric oxide; autoimmunity; EAE
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Funding
- Lottery Health Research Committee
- Health Research Council of New Zealand
- Wellington Medical Research Foundation
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In certain disease context, cells of the monocyte/macrophage lineage are known to exhibit T-cell suppressor function. However, whether naive monocytes are also able to suppress T-cell responses has not been previously investigated. In this study, we have discovered that CD11b(+)Ly6G(-) mononuclear cells in the blood of naive mice are potent suppressors of T-cell proliferation in vitro. The suppression of T-cell proliferation requires cell-cell contact and is partially dependent on nitric oxide production. Following the induction of experimental autoimmune encephalomyelitis in mice, the suppressor function of this blood CD11b(+)Ly6G(-) cell population is impaired. Therefore, blood CD11b(+)Ly6G(-) cells appear to be intrinsically suppressive and may have a key role in maintaining immune homoeostasis. Loss of this suppressive function may contribute to development of autoimmunity. Immunology and Cell Biology (2011) 89, 7-13; doi:10.1038/icb.2010.110; published online 9 November 2010
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