Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 88, Issue 3, Pages 250-256Publisher
WILEY
DOI: 10.1038/icb.2009.115
Keywords
Th2; eosinophil; allergy; helminth
Categories
Funding
- NIH [AI020241, AI051645]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL095699] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI020241, R01AI020241, R01AI051645] Funding Source: NIH RePORTER
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Eosinophils, innate immune leukocytes elicited by Th2 cells, have long been associated with the effector arm of Th2 immune responses. However, accumulating data over the past decade reveal a much more dynamic picture of Th2 immunity, where eosinophils are present very early in response to Th2-inducing agents and function in the initiation of Th2 immunity. Here we discuss recent data showing immune functions of eosinophils distinct from their previously appreciated tissue-and helminth-destructive capacities, providing strong evidence for a new paradigm of Th2 immunity defined by a dynamic interplay between eosinophils and T cells. Immunology and Cell Biology (2010) 88, 250-256; doi: 10.1038/icb.2009.115; published online 12 January 2010
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