Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 88, Issue 1, Pages 3-12Publisher
WILEY
DOI: 10.1038/icb.2009.90
Keywords
macrophages; mouse; bone marrow; spleen; differentiation
Categories
Funding
- Queen's University (ARC)
- NSERC
- CCFC
- Robert Wilson Fellowship
- Libyan Government
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The initiation of T-cell immune responses requires professional antigen-presenting cells. Emerging data point towards an important role for macrophages (M phi) in the priming of naive T cells. In this study we analyzed the efficiency and the mechanisms by which M phi derived from spleen (Sp-M phi) or bone marrow (BM-M phi) present Lymphocytic choriomeningitis virus (LCMV) antigens to epitope-specific T cells. We demonstrate that because of phagosomal maturation, Sp-M phi downregulate their ability to cross-present cell-associated, but not soluble, antigens, as they are further differentiated in culture without altering their capacity to directly present virus antigens after infection. We propose that Sp-M phi are extremely efficient at direct and cross-presentation. However, if these cells undergo further M-CSF-dependent maturation, they will adapt to be more scavenger and phagocytic and concurrently reduce their cross-presenting capacity. Accordingly, Sp-M phi can have an important role in regulating T-cell responses through cross-presentation depending on their differentiation state. Immunology and Cell Biology (2010) 88, 3-12; doi:10.1038/icb.2009.90; published online 24 November 2009
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