Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 86, Issue 4, Pages 312-319Publisher
WILEY
DOI: 10.1038/icb.2008.12
Keywords
T cells; cytokines; MHC ligands; thymus
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The pool of mature T cells comprises a heterogeneous mixture of naive and memory CD4(+) and CD8(+) cells. These cells are long lived at a population level but differ markedly in their relative rates of turnover and survival. Here, we review how contact with exogenous stimuli, notably self MHC ligands and various gamma(c) cytokines, plays a decisive role in controlling normal T cell homeostasis.
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