Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 34, Issue 2, Pages 263-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2014.01.001
Keywords
Mast cell; hTryptase-beta; mMCP-6; mMCP-7; Fibrinogen; Fibrin thrombin-dependent coagulation; Anaphylaxis
Categories
Funding
- NIH [AI059746]
- Mastocytosis Society
Ask authors/readers for more resources
Tetramer-forming tryptase (hTryptase-beta) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-beta is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-beta could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-beta has potential to be used in clinical settings where it is desirable to inhibit blood coagulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available