Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 33, Issue 2, Pages 177-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2012.10.003
Keywords
Genetic association; Hypersensitivity; Nonsteroidal anti-inflammatory drugs
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Funding
- Ministry of Health and Welfare, ROK [A111218-11-PG01]
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Various hypersensitivity reactions have been reported with aspirin and nonsteroidal anti-inflammatory drugs. Hypersensitivity can occur regardless of a chemical drug structure or its therapeutic potency. Allergic conditions include aspirin-exacerbated respiratory disease (AERD or aspirin-induced asthma), aspirin-induced urticaria/angioedema (AIU), and anaphylaxis. Several genetic studies on aspirin hypersensitivity have been performed to discover the genetic predisposition to aspirin hypersensitivity and to gain insight into the phenotypic diversity. This article updates data on the genetic mechanisms that govern AERD and AIU and summarizes recent findings on the molecular genetic mechanism of aspirin hypersensitivity.
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