Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 30, Issue 3, Pages 397-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2010.05.005
Keywords
Vitamin D; Atopic dermatitis; Asthma; Allergy
Categories
Funding
- NIH [AR 41256, N01 AI 40029]
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This review examines the scientific evidence behind the hypothesis that vitamin D plays a role in the pathogenesis of allergic diseases, along with a focus on emerging data regarding vitamin D and atopic dermatitis. Elucidated molecular interactions of vitamin D with components of the immune system and clinical data regarding vitamin D deficiency and atopic diseases are discussed. The rationale behind the sunshine hypothesis, laboratory evidence supporting links between vitamin D deficiency and allergic diseases, the clinical evidence for and against vitamin D playing a role in allergic diseases, and the emerging evidence regarding the potential use of vitamin D to augment the innate immune response in atopic dermatitis are reviewed.
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