Journal
IMMUNOLOGY
Volume 156, Issue 1, Pages 23-32Publisher
WILEY
DOI: 10.1111/imm.13005
Keywords
B cells; neutrophils; T cells
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Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [IG20339]
- Ministero dell'Istruzione, dell'Universita e della Ricerca [PRIN 2015YYKPNN]
- COST Action [BM1404 Mye-EUNI3TER]
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An increasing body of literature supports a role for neutrophils as players in the orchestration of adaptive immunity. During acute and chronic inflammatory conditions, neutrophils rapidly migrate not only to sites of inflammation, but also to draining lymph nodes and spleen, where they engage bidirectional interactions with B- and T-lymphocyte subsets. Accordingly, a relevant role of neutrophils in modulating B-cell responses under homeostatic conditions has recently emerged. Moreover, specialized immunoregulatory properties towards B or T cells acquired by distinct neutrophil populations, originating under pathological conditions, have been consistently described. In this article, we summarize the most recent data from human studies and murine models on the ability of neutrophils to modulate adaptive immune responses under physiological and pathological conditions and the mechanisms behind these processes.
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