Journal
IMMUNOLOGY
Volume 156, Issue 1, Pages 69-73Publisher
WILEY
DOI: 10.1111/imm.13000
Keywords
C3; complement; FcR; in vivo; infection; Salmonella
Categories
Funding
- University of Cambridge
- Biotechnology and Biological Research Council (BBSRC)
- BBSRC [BB/M000982/1] Funding Source: UKRI
- MRC [G0001245] Funding Source: UKRI
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Vaccines can serve as essential tools to prevent bacterial diseases via the induction of long-lasting IgG responses. The efficacy of such vaccines depends on the effector mechanisms triggered by IgG. The complement system and Fc-gamma receptors (FcRs) can potentially play a crucial role in IgG-mediated immunity against bacterial diseases. However, their relative importance in vivo is unclear, and has been the object of controversy and debate. In this brief study, we have used gene-targeted mice lacking either FcRI, II, II and IV or the C3 complement component as well as a novel mouse strain lacking both C3 and FcRs to conclusively show the essential role of complement in antibody-mediated host resistance to Salmonella enterica systemic infection. By comparing the effect of IgG2a antibodies against Salmonella O-antigen in gene-targeted mice, we demonstrate that the complement system is essential for the IgG-mediated reduction of bacterial numbers in the tissues.
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