Journal
IMMUNOLOGY
Volume 142, Issue 1, Pages 39-45Publisher
WILEY-BLACKWELL
DOI: 10.1111/imm.12228
Keywords
differentiation; vitamin A; dendritic cell; mucosa
Categories
Funding
- Dutch Scientific Research program (NWO grant) [836.08.003]
Ask authors/readers for more resources
Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differentiation of CD11b(+) DC subsets in the mucosa as well as the spleen depend on vitamin A signalling. As CD11b(+) DC subsets exert non-redundant functions in anti-bacterial and anti-fungal immune responses, defects in CD11b(+) DC differentiation will contribute to the clinical problems observed during vitamin A deficiency.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available