Journal
IMMUNOLOGY
Volume 137, Issue 2, Pages 139-148Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2567.2012.03625.x
Keywords
CD8; co-receptor; biophysics; crystal structure; peptide-major histocompatibility complex; T-cell activation; T-cell receptor
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CD8+similar to T cells respond to signals mediated through a specific interaction between the T-cell receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between the polymorphic a1 and a2 helices of an MHC class I (MHCI) molecule. The CD8 glycoprotein co-receives antigen by binding to an invariant region of the MHCI molecule and can enhance ligand recognition by up to 1 similar to million-fold. In recent years, a number of structural and biophysical investigations have shed light on the role of the CD8 co-receptor during T-cell antigen recognition. Here, we provide a collated resource for these data, and discuss how the structural and biophysical parameters governing CD8 co-receptor function further our understanding of T-cell cross-reactivity and the productive engagement of low-affinity antigenic ligands.
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