Journal
IMMUNOLOGICAL REVIEWS
Volume 285, Issue 1, Pages 218-232Publisher
WILEY
DOI: 10.1111/imr.12694
Keywords
mathematical modeling; T cells; thymic development
Categories
Funding
- National Institutes of Health [R01 AI093870]
- Medical Research Council [MR/P011225/1]
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Generating and maintaining a diverse repertoire of naive T cells is essential for protection against pathogens, and developing a mechanistic and quantitative description of the processes involved lies at the heart of our understanding of vertebrate immunity. Here, we review the biology of naive T cells from birth to maturity and outline how the integration of mathematical models and experiments has helped us to develop a full picture of their life histories.
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