Journal
IMMUNOLOGICAL REVIEWS
Volume 259, Issue 1, Pages 231-244Publisher
WILEY
DOI: 10.1111/imr.12169
Keywords
autoimmunity; Treg; multiple sclerosis; FoxP3; regulatory T cells; Tr1
Categories
Funding
- National MS Society Collaborative Research Center [CA1061-A-18]
- National Institutes of Health [P01 AI045757, U19 AI046130, U19 AI070352, P01 AI039671]
- National Institute of Neurological Disorders and Stroke [NS2427]
- Penates Foundation
- Nancy Taylor Foundation for Chronic Diseases, Inc.
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Regulatory T cells are the central element for the maintenance of peripheral tolerance. Several subtypes of regulatory T (Treg) cells have been described, and most of them belong to the CD4(+) T-helper (Th) cell lineage. These specific subtypes can be discriminated according to phenotype and function. Forkhead box protein 3 (FoxP3)-expressing natural Treg cells (Tregs) and IL-10-producing, T-regulatory type 1 cells (Tr1) are the best-studied types of CD4(+) regulatory T cells in humans and experimental animal models. It was shown that they play a crucial role during autoimmune neuroinflammation. Both cells types seem to be particularly important for multiple sclerosis (MS). Here, we discuss the role of CD4(+) regulatory T cells in autoimmune neuroinflammation with an emphasis on Tregs and Tr1 cells in MS.
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