Journal
IMMUNOLOGICAL REVIEWS
Volume 260, Issue 1, Pages 221-234Publisher
WILEY
DOI: 10.1111/imr.12191
Keywords
IL-15; celiac disease; tissue; autoimmunity; cytotoxic T cells; loss of oral tolerance
Categories
Funding
- University Of Chicago Celiac Disease Center
- Digestive Diseases Research Core Center at the University of Chicago [DK42086]
- US National Institutes of Health [RO1DK67180]
- Canadian Celiac Association
- Canadian Institutes of Health Research
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Interleukin-15 (IL-15) exerts many biological functions essential for the maintenance and function of multiple cell types. Although its expression is tightly regulated, IL-15 upregulation has been reported in many organ-specific autoimmune disorders. In celiac disease, an intestinal inflammatory disorder driven by gluten exposure, the upregulation of IL-15 expression in the intestinal mucosa has become a hallmark of the disease. Interestingly, because it is overexpressed both in the gut epithelium and in the lamina propria, IL-15 acts on distinct cell types and impacts distinct immune components and pathways to disrupt intestinal immune homeostasis. In this article, we review our current knowledge of the multifaceted roles of IL-15 with regard to the main immunological processes involved in the pathogenesis of celiac disease.
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