Journal
IMMUNOLOGICAL REVIEWS
Volume 260, Issue 1, Pages 118-128Publisher
WILEY
DOI: 10.1111/imr.12181
Keywords
epithelial cells; dendritic cells; microbiota; antimicrobial peptides; probiotics
Categories
Funding
- EU (ERC: Dendroworld)
- EU (ERC: HomeoGUT)
- Italian Association for Cancer Research (AIRC)
- Italian Ministry of Health (Ricerca finalizzata)
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Intestinal epithelial cells are fundamental to maintain barrier integrity and to participate in food degradation and absorption, but they can also decipher signals coming from the outside world and educate' the immune system accordingly. In particular, they interact with dendritic cells (DCs) and other intraepithelial immune cells to drive tolerogenic responses under steady state, but they can also release immune mediators to recruit inflammatory cells and to elicit immunity to infectious agents. When these interactions are deregulated, immune disorders can develop. In this review, we discuss some important features of epithelial cells and DCs and their fruitful interactions.
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