Journal
IMMUNOLOGICAL REVIEWS
Volume 256, Issue 1, Pages 222-239Publisher
WILEY
DOI: 10.1111/imr.12118
Keywords
chemotaxis; GPCR; CSF-1; WASP; WAVE; Arp2; 3; phagocytosis
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Funding
- NIH [GM071828]
- Cellular, Molecular Biology and Genetics training grant [GM007491]
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Macrophages are best known for their protective search and destroy functions against invading microorganisms. These processes are commonly known as chemotaxis and phagocytosis. Both of these processes require actin cytoskeletal remodeling to produce distinct F-actin-rich membrane structures called lamellipodia and phagocytic cups. This review will focus on the mechanisms by which macrophages regulate actin polymerization through initial receptor signaling and subsequent Arp2/3 activation by nucleation-promoting factors like the WASP/WAVE family, followed by remodeling of actin networks to produce these very distinct structures.
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