Journal
IMMUNOLOGICAL REVIEWS
Volume 257, Issue 1, Pages 14-38Publisher
WILEY
DOI: 10.1111/imr.12136
Keywords
adoptive cell therapy; immunotherapy; chimeric antigen receptor; cancer; immune modulation; tumor microenvironment
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Funding
- Societa Italiana di Ematologia Sperimentale (SIES)
- Associazione Italiana Pazienti Emopatici (AIPE)
- AFCRI from the University of Pennsylvania [990-9936-4-900278-5043 2433 1410]
- development and commercialization of CART19 technology
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Recent clinical success has underscored the potential for immunotherapy based on the adoptive cell transfer (ACT) of engineered T lymphocytes to mediate dramatic, potent, and durable clinical responses. This success has led to the broader evaluation of engineered T-lymphocyte-based adoptive cell therapy to treat a broad range of malignancies. In this review, we summarize concepts, successes, and challenges for the broader development of this promising field, focusing principally on lessons gleaned from immunological principles and clinical thought. We present ACT in the context of integrating T-cell and tumor biology and the broader systemic immune response. Video podcast available Go to www.immunologicalreviews.com to watch an interview with Guest Editor Dr Carl June.
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