Journal
IMMUNOLOGICAL REVIEWS
Volume 253, Issue -, Pages 40-52Publisher
WILEY
DOI: 10.1111/imr.12045
Keywords
natural killer; NK; microRNA; development; cytotoxicity
Categories
Funding
- NIH T32 award [CA009149]
- Searle Scholars Program
- Cancer Research Institute
- NIH [AI085034, AI100874, AI068129]
- American Cancer Society
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The important role of microRNAs in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific microRNAs in regulating the development and function of natural killer (NK) cells. Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation.
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