Journal
IMMUNOLOGICAL REVIEWS
Volume 251, Issue -, Pages 125-142Publisher
WILEY
DOI: 10.1111/imr.12013
Keywords
extracellular vesicles; microRNA; immune synapse; T cell; antigen-presenting cell
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Funding
- Comunidad de Madrid
- Spanish Ministry of Education
- Instituto de Salud Carlos III
- Spanish Ministry of the Economy
- Pro-CNIC Foundation
- [SAF2011-25834]
- [ERC-2011-AdG 294340-GENTRIS]
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The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen-presenting cells (APCs) has been described, involving exchange of extracellular vesicles (EVs) during the formation of the immunological synapse (IS). EVs, a term that encompasses exosomes and microvesicles, has been implicated in cell-cell communication during immune responses associated with tumors, pathogens, allergies, and autoimmune diseases. This review focuses on EV transfer as a mechanism for the exchange of molecules during immune cell-cell interactions.
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