Journal
IMMUNOLOGICAL REVIEWS
Volume 246, Issue -, Pages 221-238Publisher
WILEY
DOI: 10.1111/j.1600-065X.2011.01092.x
Keywords
computational models; I?B control; temporal control; signaling dynamics; dose-response control; negative feedback
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Funding
- NIH [GM071573, CA141722, AI08345]
- Wellcome Trust DBT India Alliance
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Mathematical modeling has proved to be a critically important approach in the study of many complex networks and dynamic systems in physics, engineering, chemistry, and biology. The nuclear factor ?B (NF-?B) system consists of more than 50 proteins and protein complexes and is both a highly networked and dynamic system. To date, mathematical modeling has only addressed a small fraction of the molecular species and their regulation, but when employed in conjunction with experimental analysis has already led to important insights. Here, we provide a personal account of studying how the NF-?B signaling system functions using mathematical descriptions of the molecular mechanisms. We focus on the insights gained about some of the key regulatory components: the control of the steady state, the signaling dynamics, and signaling crosstalk. We also discuss the biological relevance of these regulatory systems properties.
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