Journal
IMMUNOLOGICAL REVIEWS
Volume 246, Issue -, Pages 239-253Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-065X.2012.01107.x
Keywords
IKK; NF-?B; NEMO
Categories
Funding
- NIH [AI048034]
- Cancer Center [P30 CA014195-38]
- Sanofi Aventis
- H.N. and Frances C. Berger Foundation
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The inhibitor of nuclear factor-?B (I?B) kinase (IKK) complex is the master regulator of the NF-?B signaling pathway. The activation of the IKK complex is a tightly regulated, highly stimulus-specific, and target-specific event that is essential for the plethora of functions attributed to NF-?B. More recently, NF-?B-independent roles of IKK members have brought increased complexity to its biological function. This review highlights some of the major advances in the studies of the process of IKK activation and the biological roles of IKK family members, with a focus on NF-?B-independent functions. Understanding these complex processes is essential for targeting IKK for therapeutics.
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