Journal
IMMUNOLOGICAL REVIEWS
Volume 240, Issue -, Pages 211-234Publisher
WILEY
DOI: 10.1111/j.1600-065X.2010.00982.x
Keywords
Brucella; innate immunity; virulence factors; adaptive immunity
Categories
Funding
- FIDA
- Universidad Nacional de Costa Rica
- FS-Conare UNA/UCR IFEG29 Costa Rica
- NeTropica [P00059, F00013-02]
- MICIT/CONICIT
- Fundacion CRUSA-CSIC
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Brucella is an intracellular bacterial pathogen that causes abortion and infertility in mammals and leads to a debilitating febrile illness that can progress into a long lasting disease with severe complications in humans. Its virulence depends on survival and replication properties in host cells. In this review, we describe the stealthy strategy used by Brucella to escape recognition of the innate immunity and the means by which this bacterium evades intracellular destruction. We also discuss the development of adaptive immunity and its modulation during brucellosis that in course leads to chronic infections. Brucella has developed specific strategies to influence antigen presentation mediated by cells. There is increasing evidence that Brucella also modulates signaling events during host adaptive immune responses.
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