Related references
Note: Only part of the references are listed.An six-amino acid motif in the α3 domain of MICA is the cancer therapeutic target to inhibit shedding
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
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Platelet-Derived Transforming Growth Factor-β Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity
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ULBP6/RAET1L is an additional human NKG2D ligand
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EUROPEAN JOURNAL OF IMMUNOLOGY (2009)
Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice
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Interferon-γ down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells
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Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress
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JOURNAL OF IMMUNOLOGY (2009)
Cutting Edge: The Metalloproteinase ADAM17/TNF-α-Converting Enzyme Regulates Proteolytic Shedding of the MHC Class I-Related Chain B Protein
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JOURNAL OF IMMUNOLOGY (2009)
Costimulation of Dendritic Epidermal γδ T Cells by a New NKG2D Ligand Expressed Specifically in the Skin
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JOURNAL OF IMMUNOLOGY (2009)
Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function
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JOURNAL OF IMMUNOLOGY (2009)
NKG2D Ligand MICA Is Retained in the cis-Golgi Apparatus by Human Cytomegalovirus Protein UL142
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Murine NKG2D ligands: Double, double toil and trouble
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MOLECULAR IMMUNOLOGY (2009)
Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1ε in addition to MULT-1 and H60
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MOLECULAR IMMUNOLOGY (2009)
HIV-1 Vpr Triggers Natural Killer Cell-Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response
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PLOS PATHOGENS (2009)
Natural killer cell evasion by an E3 ubiquitin ligase from Kaposi's sarcoma-associated herpesvirus
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BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways
Jerome D. Coudert et al.
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Tumor-associated MICA is shed by ADAM proteases
Inja Waldhauer et al.
CANCER RESEARCH (2008)
NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells
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EUROPEAN RESPIRATORY JOURNAL (2008)
NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
Nadia Guerra et al.
IMMUNITY (2008)
Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB
Kai-Fu Tang et al.
JOURNAL OF CELL BIOLOGY (2008)
Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D
Akio Takada et al.
JOURNAL OF IMMUNOLOGY (2008)
Interaction of Monocytes with NK Cells upon Toll-Like Receptor-Induced Expression of the NKG2D Ligand MICA
Mercedes Kloss et al.
JOURNAL OF IMMUNOLOGY (2008)
Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
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NATURE IMMUNOLOGY (2008)
Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D
Noam Stern-Ginossar et al.
NATURE IMMUNOLOGY (2008)
A role for NKG2D in NK cell-mediated resistance to poxvirus disease
Min Fang et al.
PLOS PATHOGENS (2008)
NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells:: Evidence for a protective role in virus-induced encephalitis
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JOURNAL OF VIROLOGY (2008)
Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus
Silvia Vilarinho et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection
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INTERNATIONAL IMMUNOLOGY (2007)
HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts
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Regulation of ligands for the activating receptor NKG2D
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Host immune system gene targeting by a viral miRNA
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SCIENCE (2007)
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK-cell lysis
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BLOOD (2007)
RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
In Vivo Expression Pattern of MICA and MICB and Its Relevance to Auto-Immunity and Cancer
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PLOS ONE (2007)
CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions
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GASTROENTEROLOGY (2007)
Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands
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Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
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BLOOD (2007)
In vivo selection for metastasis promoting genes in the mouse
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection
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Low expression of CD161 and NKG2D activating NK receptor is associated with impaired NK cell cytotoxicity in metastatic melanoma patients
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Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B Ligands of NKG2D
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Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity
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Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells
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IMMUNOLOGICAL REVIEWS (2006)
TGF-β and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells
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Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
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JOURNAL OF IMMUNOLOGY (2006)
The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60
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JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity
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BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia
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JOURNAL OF IMMUNOLOGY (2006)
Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients
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INTERNATIONAL JOURNAL OF CANCER (2006)
Placenta-derived soluble MHC class I, chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: A possible novel immune escape mechanism for fetal survival
Lucia Mincheva-Nilsson et al.
JOURNAL OF IMMUNOLOGY (2006)
Proteolytic release of soluble UL16-binding protein 2 from tumor cells
I Waldhauer et al.
CANCER RESEARCH (2006)
Release of MICB molecules by tumor cells: Mechanism and soluble MICB in sera of cancer patients
Helmut Rainer Salih et al.
HUMAN IMMUNOLOGY (2006)
Regulation of NKG2D ligand gene expression
Robert A. Eagle et al.
HUMAN IMMUNOLOGY (2006)
IFN-Dependent down-regulation of the NKG2D ligand H60 on tumors
JD Bui et al.
JOURNAL OF IMMUNOLOGY (2006)
Cutting edge: The AP-1 subunit JunB determines NK cell-mediated target cell killing by regulation of the NKG2D-Ligand RAE-1 epsilon
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JOURNAL OF IMMUNOLOGY (2006)
Soluble ULBP suppresses natural killer cell activity via down-regulating NKG2D expression
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CELLULAR IMMUNOLOGY (2006)
Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection
JM Routes et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas
M Jinushi et al.
JOURNAL OF HEPATOLOGY (2005)
Inhibition of NK cell activity through TGF-β1 by down-regulation of NKG2D in a murine model of head and neck cancer
S Dasgupta et al.
JOURNAL OF IMMUNOLOGY (2005)
Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity
CE Andoniou et al.
NATURE IMMUNOLOGY (2005)
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
DE Oppenheim et al.
NATURE IMMUNOLOGY (2005)
Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts
K Ogasawara et al.
NATURE IMMUNOLOGY (2005)
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
S Gasser et al.
NATURE (2005)
Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo
K Wiemann et al.
JOURNAL OF IMMUNOLOGY (2005)
The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure
D Garrity et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias
P Nowbakht et al.
BLOOD (2005)
Cutting edge:: NKG2D is a costimulatory receptor for human naive CD8+ T cells
K Maasho et al.
JOURNAL OF IMMUNOLOGY (2005)
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
J Bartkova et al.
NATURE (2005)
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
VG Gorgoulis et al.
NATURE (2005)
Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein
M Hasan et al.
JOURNAL OF VIROLOGY (2005)
Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells
LIR Ehrlich et al.
JOURNAL OF IMMUNOLOGY (2005)
Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
JD Coudert et al.
BLOOD (2005)
NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145
A Krmpotic et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Viral modulation of NK cell immunity
MB Lodoen et al.
NATURE REVIEWS MICROBIOLOGY (2005)
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D
K Eleme et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor
JA Hamerman et al.
JOURNAL OF IMMUNOLOGY (2004)
A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease
S Hüe et al.
IMMUNITY (2004)
Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer
JD Wu et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D
L Bacon et al.
JOURNAL OF IMMUNOLOGY (2004)
Elevated TGF-β1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients
JC Lee et al.
JOURNAL OF IMMUNOLOGY (2004)
The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions
MB Lodoen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
RNA interference targeting transforming growth factor-β enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo
MA Friese et al.
CANCER RESEARCH (2004)
Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma
ES Doubrovina et al.
JOURNAL OF IMMUNOLOGY (2003)
Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium
EJ Park et al.
JOURNAL OF IMMUNOLOGY (2003)
ADAMs: modulators of cell-cell and cell-matrix interactions
JM White
CURRENT OPINION IN CELL BIOLOGY (2003)
Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia
HR Salih et al.
BLOOD (2003)
Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rhe'umatoid arthritis
V Groh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells:: Up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein
A Rölle et al.
JOURNAL OF IMMUNOLOGY (2003)
Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity
C Dunn et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
ULBP4 is a novel ligand for human NKG2D
NJ Chalupny et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules
M Lodoen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein
J Wu et al.
JOURNAL OF IMMUNOLOGY (2003)
Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid
M Jinushi et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells
BA Rabinovich et al.
JOURNAL OF IMMUNOLOGY (2003)
Hyperkeratosis and leukocytosis in transgenic mice carrying MHC class I chain-related gene B (MICB)
E Nomura et al.
TISSUE ANTIGENS (2003)
Symmetry recognizing asymmetry: Analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands
BJ McFarland et al.
STRUCTURE (2003)
Critical role of MHC class I-related chain A and B expression on IFN-α-stimulated dendritic cells in NK cell activation:: Impairment in chronic hepatitis C virus infection
M Jinushi et al.
JOURNAL OF IMMUNOLOGY (2003)
A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity
A Diefenbach et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein
SA Welte et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Impairment of NK cell function by NKG2D modulation in NOD mice
K Ogasawara et al.
IMMUNITY (2003)
Thermodynamic analysis of degenerate recognition by the NKG2D immunoreceptor: Not induced fit but rigid adaptation
BJ McFarland et al.
IMMUNITY (2003)
NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
S Gilfillan et al.
NATURE IMMUNOLOGY (2002)
Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
A Diefenbach et al.
NATURE IMMUNOLOGY (2002)
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
V Groh et al.
NATURE (2002)
Cutting edge: Down-regulation of MICA on human tumors by proteolytic shedding
HR Salih et al.
JOURNAL OF IMMUNOLOGY (2002)
Cutting edge: Murine UL16-binding protein-like transcript 1: A newly described transcript encoding a high-affinity ligand for marine NKG2D
LN Carayannopoulos et al.
JOURNAL OF IMMUNOLOGY (2002)
Expression of stress-induced MHC class I related chain molecules on human melanoma
CS Vetter et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2002)
UL16-Binding proteins, novel MHC class I-Related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells
CL Sutherland et al.
JOURNAL OF IMMUNOLOGY (2002)
A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3
M Radosavljevic et al.
GENOMICS (2002)
Cutting edge: NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment
AI Roberts et al.
JOURNAL OF IMMUNOLOGY (2001)
Regulation of cutaneous malignancy by γδ T cells
M Girardi et al.
SCIENCE (2001)
Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo
A Cerwenka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
A Diefenbach et al.
NATURE (2001)
A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers
H Onda et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family
A Steinle et al.
IMMUNOGENETICS (2001)
Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 Å
DW Wolan et al.
NATURE IMMUNOLOGY (2001)
Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells
V Groh et al.
NATURE IMMUNOLOGY (2001)
ULBPs, novel MHC class I-related molecules bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
D Cosman et al.
IMMUNITY (2001)
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ
H Takayanagi et al.
NATURE (2000)
Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages
A Diefenbach et al.
NATURE IMMUNOLOGY (2000)
Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
A Cerwenka et al.
IMMUNITY (2000)
A single amino acid substitution causes loss of expression of a MICA allele
ZH Li et al.
IMMUNOGENETICS (2000)