Journal
IMMUNOLOGICAL REVIEWS
Volume 234, Issue -, Pages 55-75Publisher
WILEY
DOI: 10.1111/j.0105-2896.2009.00885.x
Keywords
dendritic cells; CD103+dendritic cells; non-lymphoid tissue; homeostasis; functional specialization
Categories
Funding
- National Institutes of Health [CA112100, HL086899, AI080884]
- NATIONAL CANCER INSTITUTE [R01CA112100] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL086899] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI080884] Funding Source: NIH RePORTER
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Dendritic cells (DCs) have been extensively studied in mice lymphoid organs, but less is known about the origin and the mechanisms that regulate DC development and function in non-lymphoid tissues. Here, we discuss recent evidence establishing the contribution of the DC-restricted lineage to the non-lymphoid tissue DC pool and discuss the mechanisms that control the homeostasis of non-lymphoid tissue DCs. We also review recent results underlining the functional specialization of tissue DCs and discuss the potential implications of these findings in tissue immunity and in the development of novel vaccine strategies.
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