Journal
IMMUNOLOGICAL REVIEWS
Volume 236, Issue -, Pages 151-166Publisher
WILEY
DOI: 10.1111/j.1600-065X.2010.00926.x
Keywords
T cells; memory; cell differentiation; viral; transcription factors; vaccination
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Funding
- NIAID NIH HHS [R01 AI066232] Funding Source: Medline
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Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector-to-memory transition, and mature into multipotent, functional memory T cells that self-renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8+ T cells.
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