Journal
IMMUNOLOGICAL REVIEWS
Volume 239, Issue -, Pages 197-208Publisher
WILEY
DOI: 10.1111/j.1600-065X.2010.00971.x
Keywords
innate immunity; PRRs; PAMPs; TLRs; APCs; adaptive immunity
Categories
Funding
- NIAID NIH HHS [R37 AI048638-12, R56 AI048638, U19 AI090023-01, R56 AI048638-09, U19 AI090023, U19 AI090023-02, R38 AI140299, R37 AI048638-11, R37 AI048638-10, R37 AI048638] Funding Source: Medline
- NIDDK NIH HHS [R37 DK057665-12, R37 DK057665-13, R37 DK057665] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI048638, U19AI090023, R56AI048638] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R37DK057665] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Vaccines represent a potent tool to prevent or contain infectious diseases with high morbidity or mortality. However, despite their widespread use, we still have a limited understanding of the mechanisms underlying the effective elicitation of protective immune responses by vaccines. Recent research suggests that this represents the cooperative action of the innate and adaptive immune systems. Immunity is made of a multifaceted set of integrated responses involving a dynamic interaction of thousands of molecules, whose list is constantly updated to fill the several empty spaces of this puzzle. The recent development of new technologies and computational tools permits the comprehensive and quantitative analysis of the interactions between all of the components of immunity over time. Here, we review the role of the innate immunity in the host response to vaccine antigens and the potential of systems biology in providing relevant and novel insights in the mechanisms of action of vaccines to improve their design and effectiveness.
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