Journal
IMMUNOLOGICAL REVIEWS
Volume 234, Issue -, Pages 199-212Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.0105-2896.2009.00884.x
Keywords
dendritic cells; human; vaccines
Categories
Funding
- NIH [P01 CA084514, U19 AIO57234, R01 CA089440, CA078846]
- Dana Foundation
- Susan Komen Foundation
- Baylor Health Care System
- Baylor Health Care System Foundation
- ANRS
- INSERM
- NATIONAL CANCER INSTITUTE [R01CA089440, R01CA078846, R01CA140602, P01CA084512] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI057234] Funding Source: NIH RePORTER
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Immunity results from a complex interplay between the antigen-non-specific innate immune system and the antigen-specific adaptive immune system. The cells and molecules of the innate system employ non-clonal recognition receptors including lectins, Toll-like receptors, NOD-like receptors, and helicases. B and T lymphocytes of the adaptive immune system employ clonal receptors recognizing antigens or their derived peptides in a highly specific manner. An essential link between innate and adaptive immunity is provided by dendritic cells (DCs). DCs can induce such contrasting states as immunity and tolerance. The recent years have brought a wealth of information on the biology of DCs revealing the complexity of this cell system. Indeed, DC plasticity and subsets are prominent determinants of the type and quality of elicited immune responses. In this article, we summarize our recent studies aimed at a better understanding of the DC system to unravel the pathophysiology of human diseases and design novel human vaccines.
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