Journal
IMMUNOLOGICAL REVIEWS
Volume 227, Issue -, Pages 150-160Publisher
WILEY
DOI: 10.1111/j.1600-065X.2008.00720.x
Keywords
DAP10; DAP12; innate immunity; immunoreceptor tyrosine-based activation motif
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Funding
- National Institutes of Health
- NATIONAL CANCER INSTITUTE [R01CA089294, R01CA095137] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI066897, P01AI064520] Funding Source: NIH RePORTER
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The DAP10 and DAP12 signaling subunits are highly conserved in evolution and associate with a large family of receptors in hematopoietic cells, including dendritic cells, plasmacytoid dendritic cells, neutrophils, basophils, eosinophils, mast cells, monocytes, macrophages, natural killer cells, and some B and T cells. Some receptors are able to associate with either DAP10 or DAP12, which contribute unique intracellular signaling functions. Studies of humans and mice deficient in these signaling subunits have provided surprising insights into the physiological functions of DAP10 and DAP12, demonstrating that they can either activate or inhibit immune responses. DAP10- and DAP12-associated receptors have been shown to recognize both host-encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses.
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