Journal
IMMUNOLOGICAL REVIEWS
Volume 228, Issue -, Pages 132-148Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1600-065X.2008.00748.x
Keywords
tyrosine kinases; B lymphocytes; B-cell receptor
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Funding
- Japanese Ministry of Education, Culture, Sports, Science and Technology
- Kanahara Foundation
- Mochida Foundation
- Naitoh Memorial Foundation
- Ciba-Geigy Foundation (Japan)
- Sumitomo Foundation
- Uehara Foundation
- Toray Science Foundation
- Takeda Foundation
- Hoh-ansha Foundation
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Gene-targeting experiments have highlighted the importance of the intracellular protein tyrosine kinases, Lyn, Syk, and Btk, in B-cell receptor-mediated phospholipase C gamma 2 and phosphoinositide 3-kinase activation. In linking such tyrosine kinases with effector enzymes, an important role has emerged for adapter molecules. Adapter proteins nucleate formation of distinct signaling complexes in a specific location within the cell and facilitate the interaction between these signaling components in this particular subcellular compartment, which, in turn, contribute to the qualitative and quantitative control of B-cell signaling.
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