Journal
IMMUNOLOGICAL REVIEWS
Volume 231, Issue -, Pages 160-173Publisher
WILEY
DOI: 10.1111/j.1600-065X.2009.00809.x
Keywords
CTLs; lytic granules; cytotoxicity; calcineurin; exocytosis
Categories
Funding
- NIAID [AI42964, AI054839]
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Cytotoxic T lymphocytes (CTLs) kill targets by releasing cytotoxic agents from lytic granules. Killing is a multi-step process. The CTL adheres to a target, allowing its T-cell receptors to recognize antigen. This triggers a signal transduction cascade that leads to the polarization of the microtubule cytoskeleton and granules towards the target, followed by exocytosis that occurs specifically at the site of contact. As with cytokine production by helper T cells (Th cells), target cell killing is absolutely dependent on Ca
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