Journal
IMMUNOLOGICAL REVIEWS
Volume 231, Issue -, Pages 241-256Publisher
WILEY
DOI: 10.1111/j.1600-065X.2009.00821.x
Keywords
cell differentiation; signal transduction; osteoclast; calcium oscillation; NFATc1; costimulatory signaling
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Funding
- Japan Society for the Promotion of Science (JSPS)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
- Takeda Life Science Foundation
- Yokoyama Foundation for Clinical Pharmacology
- Ichiro Kanehara Foundation
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Osteoclasts are unique, multinucleated giant cells that decalcify and degrade the bone matrix. They originate from hematopoietic cells and their differentiation is dependent on a tumor necrosis factor (TNF) family cytokine, receptor activator of nuclear factor-kappa B (NF-kappa B) ligand (RANKL), as well as macrophage-colony stimulating factor (M-CSF). Recent studies have unveiled the precise molecular mechanism underlying osteoclastogenesis. In particular, the discovery of nuclear factor of activated T cells c1 (NFATc1), the master regulator of osteoclastogenesis, has proven to be a breakthrough in this field. NFATc1 is activated by Ca
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