Journal
IMMUNOLOGICAL REVIEWS
Volume 228, Issue -, Pages 241-252Publisher
WILEY
DOI: 10.1111/j.1600-065X.2008.00759.x
Keywords
serine/threonine kinase; diacylglycerol; PI-(3,4,5)-P-3; T lymphocyte; PI3-kinase; signal transduction
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Funding
- Wellcome Trust [065975] Funding Source: Medline
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The development of T lymphocytes in the thymus and the function of mature T cells in adaptive immune responses are choreographed by antigen receptors, costimulatory molecules, adhesion molecules, cytokines, and chemokines. These extrinsic stimuli are coupled to a diverse network of signal transduction pathways that control the transcriptional and metabolic programs that determine T-cell function. At the core of T-lymphocyte signal transduction is the regulated metabolism of inositol phospholipids and the production of two key lipid second messengers: polyunsaturated diacylglycerols (DAGs) and phosphatidylinositol (3-5) triphosphate [PI-(3-5)-P-3]. The object of the present review is to discuss facts, controversies, and unresolved issues about DAG and PI-(3,4,5)-P-3 production in T lymphocytes and to discuss some of the serine/threonine kinases that control unique aspects of T-lymphocyte biology and coordinate T-cell participation in adaptive immune responses.
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