Journal
IMMUNOLOGICAL REVIEWS
Volume 222, Issue -, Pages 101-116Publisher
WILEY
DOI: 10.1111/j.1600-065X.2008.00614.x
Keywords
ovarian cancer; ascites; prognosis; effector T cells; regulatory T cells; cytokines; immunotherapy
Categories
Funding
- NCI NIH HHS [P50 CA083636, CA83636] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P50CA083636] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Ovarian cancer remains a challenging disease for which improved treatments are urgently needed. Most patients present with advanced disease that is highly responsive to surgery combined with platinum- and taxane-based chemotherapy, with a state of minimal residual disease being achieved in many cases. However, chemotherapy-resistant recurrent tumors typically appear within 1-5 years and are ultimately fatal. Recently, several groups have shown that ovarian tumors are often infiltrated by activated T cells at the time of diagnosis, and patients with dense infiltrates of CD3(+)CD8(+) T cells experience unexpectedly favorable progression-free and overall survival. Other cell types in the immune infiltrate oppose anti-tumor immunity, including CD4(+)CD25(+)FoxP3(+) regulatory T cells, CD8(+) regulatory T cells, macrophages, and dendritic cells. The composition of immune infiltrates is shaped by the expression of cytokines, chemokines, antigens, major histocompatibility complex molecules, and costimulatory molecules. The relationship between these various immunological factors is reviewed here with a strong emphasis on outcomes data so as to create a knowledge base that is well grounded in clinical reality. With improved understanding of the functional properties of natural CD8(+) T-cell responses to ovarian cancer, there is great potential to improve clinical outcomes by amplifying host immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available