Journal
IMMUNOLOGICAL REVIEWS
Volume 222, Issue -, Pages 328-340Publisher
WILEY
DOI: 10.1111/j.1600-065X.2008.00611.x
Keywords
tumor-associated antigens; TAA miniarrays; anti-TAA profiles; therapeutic response monitors; immune system reporters; auto-epitope immunotherapy
Categories
Funding
- NATIONAL CANCER INSTITUTE [R01CA056956] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [G12RR008124] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [S06GM008012] Funding Source: NIH RePORTER
- NCI NIH HHS [CA56956, R01 CA056956] Funding Source: Medline
- NCRR NIH HHS [5G12RR008124, G12 RR008124] Funding Source: Medline
- NIGMS NIH HHS [S06 GM008012-380010, 2SO6GM008012-37, S06 GM008012, S06 GM008012-370010] Funding Source: Medline
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Although autoantibodies have been recognized as participants in pathogenesis of tissue injury, the collateral role of autoantibodies as reporters from the immune system identifying cellular participants in tumorigenesis has not been fully appreciated. The immune system appears to be capable of sensing aberrant structure, distribution, and function of certain cellular components involved in tumorigenesis and making autoantibody responses to the tumor-associated antigens (TAAs). Autoantibodies to TAAs can report malignant transformation before standard clinical studies and may be useful as early detection biomarkers. The autoantibody response also provides insights into factors related to how cellular components may be rendered immunogenic. As diagnostic biomarkers, specific TAA miniarrays for identifying autoantibody profiles could have sufficient sensitivity in differentiating between types of tumors. Such anti-TAA profiles could also be used to monitor response to therapy. The immune system of cancer patients reveals the immune interactive sites or the autoepitopes of participants in tumorigenesis, and this information should be used in the design of immunotherapy.
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