Journal
IMMUNOLOGICAL INVESTIGATIONS
Volume 41, Issue 6-7, Pages 738-764Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/08820139.2012.676122
Keywords
Dendritic Cells; Indoleamine 2,3-dioxygenase; Immune tolerance
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Funding
- NCI NIH HHS [R01 CA100656] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA100656] Funding Source: NIH RePORTER
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This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and the associated immunological outcomes. The review will conclude with a discussion of the poorly defined mechanisms that mediate the long-term maintenance of IDO-expression in response to inflammatory stimuli and how selective modulation of IDO activity may be used in the treatment of disease.
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