Journal
IMMUNOLOGIC RESEARCH
Volume 57, Issue 1-3, Pages 99-105Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-013-8459-y
Keywords
Chitinase-3-like-1 protein; Angiogenesis; Inflammation; Metastasis; Chitin
Categories
Funding
- National Institutes of Health [NIH R15 CA135513-01, R15 CA135513-01-OS1]
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Elevated serum levels of a glycoprotein known as chitinase-3-like protein 1 (CHI3L1) have been correlated with poor prognosis and shorter survival of patients with cancer and inflammatory diseases. The biological and physiological functions of CHI3L1 in cancer have not yet been completely elucidated. In this review, we describe the role of CHI3L1 in inducing pro-inflammatory/pro-tumorigenic and angiogenic factors that could promote tumor growth and metastasis.
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