Journal
IMMUNOLOGIC RESEARCH
Volume 54, Issue 1-3, Pages 4-13Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-012-8307-5
Keywords
B cells; Innate immune cells; Splenic marginal zone; Intestinal mucosa; Class switching
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Funding
- US National Institutes of Health [R01 AI074378, P01 AI61093, U01 AI95613, P01 096187]
- Ministerio de Ciencia e Innovacion [SAF 2008-02725]
- EUROPADnet [HEALTH-F2-2008-201549]
- Sara Borrell post-doctoral fellowship
- Juan de la Cierva post-doctoral fellowships
- ICREA Funding Source: Custom
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Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T-cell-dependent pathway provides immunological memory but is relatively slow to occur. Thus, it must be integrated with a faster, T-cell-independent pathway for B-cell activation through CD40 ligand-like molecules that are released by innate immune cells in response to microbial products. Here, we discuss recent advances in our understanding of the interplay between the innate immune system and B cells, particularly frontline B cells located in the marginal zone of the spleen and in the intestine.
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