Journal
IMMUNOLOGIC RESEARCH
Volume 49, Issue 1-3, Pages 269-280Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-010-8188-4
Keywords
Monoclonal B lymphocytosis; Chronic lymphocytic leukemia; Non-Hodgkin's lymphoma; B-cell receptor; B-cell development
Categories
Funding
- Leukemia and Lymphoma Society of America
- Bernstein Fund for Leukemia Research
- VA Research Service
- National Institutes of Health [NCI R03 CA128030, CA118444, CA92153]
- National Cancer Institute [CA15083]
- CLL Research Consortium
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Monoclonal B-cell lymphocytosis (MBL) is a preclinical hematologic condition wherein small numbers of clonal B cells can be detected in the blood of otherwise healthy individuals. Most MBL have a surface immunophenotype nearly identical to that of chronic lymphocytic leukemia (CLL), though other phenotypes can also be identified. MBL has been shown to be a precursor state for CLL, but most MBL clones are quite small and apparently have minimal potential to progress of CLL or other B-cell lymphoproliferative disorder (B-LPD). The investigation of MBL as a precursor state for CLL will likely lead to important insights into mechanisms of disease pathogenesis. The review will cover clinical and translational aspects of MBL, with a particular emphasis on the prevalence of MBL; the relationship between MBL, CLL, and other B-LPDs; and the capacity of MBL to modulate the normal B- and T-cell compartments.
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