Journal
IMMUNOLOGIC RESEARCH
Volume 48, Issue 1-3, Pages 59-71Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-010-8167-9
Keywords
HIV; ART; CD4(+) T-cells; CD8(+) T-cells; IL-7; TAT2; Aging
Categories
Funding
- NIAID [5RO1-AI-058845]
- NIA [1RO1-AG-030327]
- National Institutes of Health under National Cancer Institute [5 T32 CA009120]
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Older individuals (a parts per thousand yen50 years of age) are increasingly becoming a new at-risk group for HIV-1 infection and, together with those surviving longer due to the introduction of anti-retroviral therapy (ART), it is predicted that more than half of all HIV-1-infected individuals in the United States will be greater than 50 years of age in the year 2015. Older individuals diagnosed with HIV-1 are prone to faster disease progression and reduced T-cell reconstitution despite successful virologic control with anti-retroviral therapy (ART). There is also growing evidence that the T-cell compartment in HIV-1(+) adults displays an aged phenotype, and HIV-1-infected individuals are increasingly diagnosed with clinical conditions more commonly seen in older uninfected persons. As aging in the absence of HIV infection is associated with alterations in T-cell function and immunosenescence, the combined impact of both HIV-1 infection and aging may provide an explanation for poorer clinical outcomes observed in older HIV-1-infected individuals. Thus, the development of novel therapeutics to stimulate immune function and delay immunosenescence is critical and would be beneficial to both the elderly and HIV-1-infected individuals.
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