Journal
IMMUNOLOGIC RESEARCH
Volume 46, Issue 1-3, Pages 216-226Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-009-8119-4
Keywords
PDT; Neutrophil; Vaccine; T cell
Categories
Funding
- NIH [CA55791, CA98156]
- Roswell Park Cancer Center [CA16056]
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Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.
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