Journal
IMMUNOLOGIC RESEARCH
Volume 43, Issue 1-3, Pages 25-61Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-008-8049-6
Keywords
Neutrophil; Cell death; Apoptosis; Phagocytosis; Pyroptosis; Autophagy; Macrophage; Inflammation; Pathogen; Innate immunity
Categories
Funding
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000900, Z01AI000900] Funding Source: NIH RePORTER
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Polymorphonuclear leukocytes (PMNs) are the most abundant white cell in humans and an essential component of the innate immune system. PMNs are typically the first type of leukocyte recruited to sites of infection or areas of inflammation. Ingestion of microorganisms triggers production of reactive oxygen species and fusion of cytoplasmic granules with forming phagosomes, leading to effective killing of ingested microbes. Phagocytosis of bacteria typically accelerates neutrophil apoptosis, which ultimately promotes the resolution of infection. However, some bacterial pathogens alter PMN apoptosis to survive and thereby cause disease. Herein, we review PMN apoptosis and the ability of microorganisms to alter this important process.
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