Journal
IMMUNOLOGIC RESEARCH
Volume 42, Issue 1-3, Pages 65-74Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-008-8035-z
Keywords
Thymus; Early T cell development; Aging; Notch
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Funding
- NIH
- Leukemia and Lymphoma Society Scholar Award
- NCI
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T cells developing in the thymus are ultimately derived from bone marrow (BM) hematopoietic stem cells (HSCs). An understanding of the developmental steps between HSCs and T cells is important for gaining insight into cancers of the T lineage, improving T cell reconstitution after BM transplantation, and also to help ameliorate immunological defects in aging. In this article, we summarize our current understanding of the inter-related fields of early T cell development and thymic aging, and briefly discuss major unresolved questions in this field.
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