Journal
IMMUNOGENETICS
Volume 64, Issue 4, Pages 261-265Publisher
SPRINGER
DOI: 10.1007/s00251-011-0584-y
Keywords
CISH; Gene variants; Hepatitis B virus; Genotype; Alleles; SNP
Categories
Funding
- Vietnamese Government
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Cytokine-inducible SRC homology 2 domain protein (CISH) is a suppressor of cytokine signaling that controls interleukin-2 signaling pathway. We investigated the single nucleotide polymorphism (SNP) -292A > T in 473 Vietnamese hepatitis B virus (HBV) carriers and 416 healthy controls. CISH variants at -292A > T were associated to HBV infection (Allelic: OR, 1.22 95% CI, 1-1.49; P = 0.04; Recessive: OR, 1.69 95% CI 1.23-2.54; P = 0.007). A gene dose effect for the risk allele -292T was observed (P = 0.04). The level of interleukin 2 and liver enzymes such as alanine transaminase, aspartate transaminase, total bilirubin, and direct bilirubin were not associated to CISH polymorphism at position -292A > T This study associated the vital role of CISH SNP -292A > T variant to hepatitis B virus infection in a Vietnamese population.
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