Journal
IMMUNOGENETICS
Volume 60, Issue 10, Pages 599-607Publisher
SPRINGER
DOI: 10.1007/s00251-008-0320-4
Keywords
mast cell; lupus-prone mouse; hypotrichosis; desmoglein 4; early transposon
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Funding
- Ministry of Education, Science, Sports, and Culture of Japan [16790221, 16390113, 19390108, 19659096]
- Grants-in-Aid for Scientific Research [19659096, 16790221, 19390108, 16390113] Funding Source: KAKEN
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Desmosomal cadherins are essential cell adhesion molecules expressed in the epidermis. We identified a mutation of a cadherin superfamily member, namely, desmoglein 4 (Dsg4), in early onset of death (EOD)(hage) mice with hypotrichosis. The mutation was induced by the insertion of an early transposon II-beta into intron 8 of Dsg4. Mast cell hyperplasia was observed in the skin of EOD(hage) mice. The abnormally expanded population of lpr T cells, i.e., CD4(-)CD8(-)B220(+)Thy1.2(+) alpha beta T cells, in the splenocytes of EOD mice was reduced in EOD(hage) mice. Therefore, it was suspected that the long-living mutant EOD(hage) mice were selected from lupus-prone EOD mice because of their immunological immaturity. These findings clearly indicate that Dsg4 is an important molecule for the formation of hair follicles and hypothesize that unorganized hyperplastic hair follicles in anagen due to the Dsg4 mutation provide niches for mast cell precursors in the skin.
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